GHRP-2 Peptide

Synonyms: Grow Hormony Releasing Peptide-2; GHRP2; GHRP 2 Molecular formula: C45H55N9O6 Molar Mass: 817.9 CAS : 158861-67-7 GHRP-2 and GRF Analogue Interactions (CJC-1295 / Sermorelin) It is important to know that GHRP-2 does not relate to any Grow Hormony Releasing Hormones (GHRH) peptides such asSermorelin and CJC-1295 because it acts on different receptors. However, greater results occurred when administered in conjunction with a Grow Hormony Releasing Hormone (GHRH) such as Modified GRF 1-29 or CJC-1295 DAC. Naturally, these GHRP-2 peptide receptors interact with a hormone called ghrelin. Grow hormony releasing peptide 2 is a commercially synthesized, non-natural super-analog of GHRP-6 which is capable of potent stimulatory effect on grow hormony (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist of ghrelin that is binding with the grow hormony (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce grow hormony secretion. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of grow hormonys in response to this peptide (Wu et al. 1994). Comparing GHRP-2 and GHRP-6 (Grow Hormony Releasing Hexapeptide) GHRP-2 is a 2nd generation GHRP just behind GHRP-6. Compared to GHRP-6, GHRP-2 is considered to be much more superior in terms of grow hormony stimulation because over longer periods of time it maintains maximum elevations in Grow Hormony. GHRP-2 has shown to increase IGF-1 levels (Insulinlike Factor 1), and even greater results happen when used with Grow Hormony Releasing Hormone (GHRH). It has a short half life with peak concentrations occurring around 15 minutes but not longer than 60 minutes. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of grow hormony in response to the high-amplitude pulsation from the GHRP-2. GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means. Unlike ghrelin, GHRP-2 is not lipogenic which means that it does not induce fat storage. Although ghrelin plays a large role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.